Publications

  1. Yong J, Johnson JD, Arvan P, *Han J, Kaufman RJ (2021) Therapeutic opportunities for pancratic b-cell ER stress in diabetes mellitus Nat Rev Endocrinol 17:455 Co-corresponding author. Cover story selected (https://media.springernature.com/w440/springer-static/cover-hires/journal/41574/17/8?as=webp&q=95).

  2. Lee J-M, Park S, Lee D, Ginting RP, Lee MR, Lee M-W, Han J. Reduction in endoplasmic reticulum stress acitvates beige adipocytes differentiation and alleviates high fat diet-induced metabolic phenotypes. (2021) Biochimica et Biophysica Acta (BBA)-Molecular Basis of Diseases 1867(5):166099

  3. Sari IN, Yang Y-G, Wijaya YT, Jun N, Lee S, Kim KS, Bajaj J, Oehler VG, Kim S-H, Choi S-Y, Park S-H, Kim D-W, Reya T, Han J, Kwon HY. (2021) AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth. Oncogene 40(3):603-617

  4. Kim HK, Bhattarai KR, Junjappa RP, Ahn JH, Pagire SH, Yoo HJ, Han J, Lee D, Kim KW, Kim HR, Chae HJ. (2020) TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation. Nat Commun. 11(1): 4012

  5. Seo J, Lee CR, Paeng JC, Kwon HW, Lee D, Kim SC, Han J, Ku JL, Chae JH, Lim BC, Choi M. (2020) Biallelic mutations in ABCB1 display recurrent reversible encephalopathy Ann. Clin. Transl. Neurol. doi: 10.1002/acn3.51125. Online ahead of print.

  6. Kwon JH, Kim HK, Ha TW, Im JS, Song BH, Hong KS, Oh JS, *Han J, *Lee MR (2020) Hyperthermia Disturbs and Delays Spontaneous Differentiation of Human Embryoid Bodies Biomedicines 8(6): 176 * co-corresponding author

  7. Ko MS, Yun JY, Baek IJ, Jang JE, Hwang JJ, Lee SE, Heo SH, Bader DA, Lee CH, Han J, Moon JS, Lee JM, Hong EG, Lee IK, Kim SW, Park JY, Hartig SM, Kang UJ, Moore DD, Koh EH, Lee KU. (2020) Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice. Autophagy https://doi.org/10.1080/15548627.2020.1753002

  8. Ha TW, Jeong JH, Shin HS, Kim HK, Im JS, Song BH, Hanna J, Oh JS, *Woo DH, *Han J, *Lee MR (2020) Characterization of Endoplasmic Reticulum (ER) in Human Pluripotent Stem Cells Revealed Increased Susceptibility to Cell Death upon ER Stress Cells 9(5): 1078 * co-corresponding author

  9. Hiramatsu N, Chiang K, Aivati C, Rodvold JJ, Lee JM, Han J, Chea L, Zanetti M, Koo EH, Lin JH (2020) PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response J. Biol. Chem. 295(1):237-249

  10. Park YJ, Choi DW, Cho SW, Han J, Yang S, Choi CY (2020) Stress Granule Formation Attenuates RACK1-Mediated Apoptotic Cell Death Induced by Morusin Int. J. Mol. Sci. 21(15), 5360

  11. Kim JS, Hwang SI, Ryu JL, Hong HS, Lee J-M, Lee SM, Jin X, Han C, Kim J-H, Han J*, Lee M-R*, Woo D-H* (2020) ER stress reliever enhances functionalities of in vitro cultured hepatocytes Stem Cell Res. 43:101732 * co-corresponding author

  12. Elviria R, Cha SJ, Noh G-M, Kim K, Han J. (2020) PERK-mediated eIF2a phosphorylation contributes to the protection of dopaminergic neurons from chronic heat stress in Drosophila Int. J. Mol. Sci. 21(3), 845 https://doi.org/10.3390/ijms21030845

  13. Lee D, Hokinson D, Park S, Elvira R, Kusuma F, Lee J-M, Yun M, Lee S-G, Han J. (2019) ER stress induces cell cycle arrest at the G2/M phase through eIF2a phosphorylation and GADD45a Int. J. Mol. Sci. 20(24), 6309 https://doi.org/10.3390/ijms20246309

  14. Park S, Lim Y, Lee D, Elvira R, Lee JM, Lee MR, Han J. (2018) Modulation of protein synthesis by eIF2a phosphorylation protects cell from heat stress-mediated apoptosis Cells 7(12).pii:E254 www.ncbi.nlm.nih.gov/pmc/articles/PMC6316477/pdf/cells-07-00254.pdf

  15. Ha TW, Kang HS, Kim TH, Kwon JH, Kim HK, Ryu A, Jeon H, Han J, Broxmeyer HE, Hwang Y, Lee YK, Lee MR. (2018) MiR-9 Controls Chemotactic Activity of Cord Blood CD34⁺ Cells by Repressing CXCR4 Expression. Int J Stem Cells 11(2):187-195

  16. Chandrahas VC, Han J*, Kaufman RJ* (2018). Coordinating organismal metabolism during protein misfolding in the ER through the unfolded protein response. Curr Top Microbiol Immunol. 414:103-130 * co-corresponding author

  17. Han J*, Kaufman RJ* (2017) Physiological/pathological ramifications of transcription factors in the unfolded protein response. Genes Dev 31(14):1417 * co-corresponding author

  18. Choi WG*, Han J*, Kim JH, Kim MJ, Park JW, Song B, Cha HJ, Choi HS, Chung HT, Lee IK, Park TS, Hatzoglou M, Choi HS, Yoo HJ, Kaufman RJ, Back SH. (2017) eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet. Nutrition metabolism 14:48. * co-first author

  19. Han J*, Kaufman RJ*. (2016) The role of ER stress in lipid metabolism. J Lipid Res 57(8):1329-1338 * co-corresponding author

  20. Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates Iii JR, Itkin-Ansari P, Volkmann N, Kaufman RJ. (2015) The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells. PLoS Biol. 13(10):e1002277.

  21. Zhou AX, Wang X, Lin CS, Han J, Yong J, Nadolski MJ, Boren J, Kaufman RJ, Tabas I. (2015) C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. Circ Res, 116(11):1736-43

  22. Han J, Song B, Kim J, Kodali VK, Pottekat A, Wang M, Hassler J, Wang S, Pennathur S, Back SH, Katze MG, Kaufman RJ. (2015) Antioxidants complement the requirement for protein chaperone function to maintain beta cell function and glucose homeostasis. Diabetes, 64(8):2892-2904

  23. Wang S, Park S, Kodali VK, Han J, Yip T, Chen Z, Davidson NO, Kaufman RJ. (2015) Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100. Molecular Biology of the Cell, 26(4):594-604

  24. Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA (2014) Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet 10(5); e1004348

  25. Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ, Lin JH (2014) Translational and posttranslational regulation of XIAP by eIF2alpha and ATF4 promotes ER stress-induced cell death during the unfolded protein response. Mol. Biol. cell 25 (9):1411-1420

  26. Han J, Kaufman RJ (2014). Measurement of the Unfolded Protein Response (UPR) to investigate its role in adipogenesis and obesity. Methods Enzymol. 538C:135-150

  27. Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, Kaufman RJ (2013) C/EBP Homologous Protein Protects Mice from Steatohepatitis. J Biol Chem 288(26):18624-42.

  28. *Krokowski D, *Han J, Saikia M, Majumder M, Yuan CL, Guan BJ, Bevilacqua E, Bussolati O, Broer S, Arvan P, Tchorzewski M, Snider MD, Puchowicz M, Croniger CM, Kimball SR, Pan T, Koromilas AE, Kaufman RJ, and Hatzoglou M. (2013). A Self-Defeating Anabolic Program Leads to beta cell apoptosis in ER Stress-Induced Diabetes via Regulation of Amino Acid Flux. J Biol Chem 288(24):17202-13

  29. *Han J, *Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, and Kaufman RJ. (2013). ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature cell biology 15(5):481-90.

  30. Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ (2013) Phosphorylation of eukaryotic translation initiation factor 2 alpha induces CHOP to suppress adipocyte differentiation Diabetologia 56(4): 911-924

  31. Oh YS, Lee YJ, Kang Y, Han J, Lim OK, and Jun HS. (2013). Exendin-4 inhibits glucolipotoxic ER stress in pancreatic beta cells via regulation of SREBP1c and C/EBPbeta transcription factors. The Journal of endocrinology, 216(3), 343-352

  32. Wang S, Chen Z, Lam V, Han J, Hassler J, Finck B, Davidson N, and Kaufman RJ (2012) IRE1 alpha-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis Cell Metab 16(4): 473-486

  33. Han J, Kim EH, Choi W, Jun HS. (2012) Glucose responsive artificial promoter-mediated insulin gene transfer improves glucose control in obese diabetic mice. World J Gastroenterol 18(44): 6420-6426

  34. Sakaki K, Yoshina S, Shen X, Han J, DeSantis RS, Xiong M, Mitani S, and Kaufman RJ (2012) RNA surveillance is required for endoplasmic reticulum homeostasis Proc Natl Acad Sci U S A 109(21): 8079-8084.

  35. Back SH, Kang SW, Han J and Chung HT (2012) ER stress in the beta cell pathogenesis of type 2 diabetes Expl Diabetes Res 2012:618396.

  36. Han J, McLane B, Kim EH, Yoon JW, and Jun HS (2011) Remission of Diabetes by Insulin Gene Therapy Using a Hepatocyte-Specific and Glucose-Responsive Synthetic Promoter Molecular Therapy 19(3):470-8

  37. Liu MJ, Han J, Lee YS, Park MS, Shin S, Jun HS. (2010) Amelioration of hyperglycemia by intestinal overexpression of glucagon-like peptide-1 in mice. J Mol Med 88(4):351-8.

  38. Kaufman RJ, Back SH, Song B, Han J, Hassler J (2010) The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes Obes Metab 12 Suppl 2:99-107.

  39. Back SH, Scheuner D, Han J et al. (2009). Translation Attenuation through eIF2a Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in b Cells Cell Metabolism 10(1): 13-26

  40. *Han J, *Lee HW, Kwon H, Shin S, Yoon JW, Jun HS (2007) Engineered enteroendocrine Cells Secrete Insulin in Response to Glucose and Reverse Hyperglycemia in Diabetic Mice. Molecular Therapy 15 (6), 1195–1202

  41. Lee YS, Hahm E, Liu M, Han J, Yoon JW, Jun HS (2006) Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis. Diabetes 56(6):1671-9

  42. Okitsu T, Kobayashi N, Jun HS, Shin S, Kim SJ, Han J, Kwon H, Sakaguchi M,Totsugawa T, Kohara M, Westerman KA, Tanaka N, Leboulch P, Yoon JW (2004) Transplantation of reversibly immortalized insulin secreting human hepatocytes controls diabetes in pancreatectomized pigs. Diabetes 3(1):105-12

  43. Hirasawa K, Kim A, Han HS, Han J, Jun HS and Yoon JW (2002) Effect of p38 Mitogen-Activated Protein Kinase on the Replication of Encephalomyocarditis Virus. J Virology 77(10):5649-56.

  44. Sobel DO, Han J, Williams J, Yoon JW, Jun HS, Ahvazi B (2002) Gamma Interferon Paradoxically Inhibits the Development of Diabetes in the NOD Mouse. J Autoimmun 19(3):129-37

  45. Jun HS, Chung YH, Han J, Kim A, Yoo S, Sherwin RS, Yoon JW (2002). Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase. Diabetologia 45(5):668-76

  46. Han J, Yoo HY, Choi BH, Rho HM. (2000) Selective transcriptional regulations in the human liver cell by hepatitis B viral X protein. Biochem Biophys Res Commun. 272(2); 525-530

  47. Lee DH, Han J, Lee WG, Lee SW, Rho HM. (1998) Quadruplex amplification of polymorphic STR loci in a Korean population. Int J Legal Med. 111(6); 320-322

  48. Han J, Lee DH, Rho HM (1998) Characteristics of hypervariable regions of mitochondrial DNA in korean population. Journal of biochemistry and molecular biology 31(6); 604-606